DNA Array-Based Gene Profiling in Tumor Immunology
نویسندگان
چکیده
منابع مشابه
DNA array-based gene profiling in tumor immunology.
Recent advances in tumor immunology have fostered the clinical implementation of different immunotherapy modalities. However, the alternate success of such regimens underscores the fact that the molecular mechanisms underlying tumor immune rejection are still poorly understood. Given the complexity of the immune system network and the multidimensionality of tumor-host interactions, the comprehe...
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BACKGROUND Abnormal DNA methylation is well established for breast cancer and contributes to its progression by silencing tumor suppressor genes. DNA methylation profiling platforms might provide an alternative approach to expression microarrays for accurate breast tumor subtyping. We sought to determine whether the distinction of the inflammatory breast cancer (IBC) phenotype from the non-IBC ...
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Subsequent to sequencing projects new strategies are required for efficient functional characterization of the identified genes. DNA array technology was proven to be a powerful tool by monitoring the transcriptional levels of all or a significant portion of genes of an organism simultaneously. Here, we present data obtained by spotting PCR products derived from yeast ORFs as high density array...
متن کاملTumor immunology.
Malignant tumors express antigens that may stimulate and serve as targets for antitumor immunity. Virally induced tumors usually contain integrated proviral genomes in theircellulargenomes and often express viral genome-encoded proteins that may stimulate specific host immune responses. Antigens unique to individual tumors that stimulate specific rejection of transplanted tumors have been demon...
متن کاملTumor immunology.
N. Franklin Adkinson, Jr. Chester A. Alper Philip W, Askenase Kenneth A. Ault Michael K. Bach Anthony Basten Michael A. Bean Celso Bianco P. E. Bigazzi R. Michael Blaese Phyllis B. Blair R. V. Blanden Kurt J. Bloch Harvey Cantor Charles B. Carpenter Bruce Chesebro Martin J. Cline Zanvil A. Cohn Daniel G, Colley Robert B, Colvin Robert B. Couch Natalie E. Cremer Susan E. Cullen Agustin P. Dalmas...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2004
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-04-0327